A-966492
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- ₹0
- Product name: A-966492
- CAS: 934162-61-5
- MF: C18H17FN4O
- MW: 324.35
- EINECS:
- MDL Number:MFCD17215207
- Synonyms:A-966492;2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide;A-966492(A 966492);2-{2-fluoro-4-[(2S)-pyrrolidin-2-yl]phenyl}-1H-1,3-benzodiazole-7-carboxaMide;2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide A-966492;A-966492, >=98%;A966492;A 966492;A-966492;CS-903
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Properties
Boiling point :605.5±65.0 °C(Predicted)
Density :1.335
storage temp. :Store at -20°C
solubility :≥32.4 mg/mL in DMSO; ≥16.53 mg/mL in H2O with ultrasonic; ≥3.16 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :9.33±0.30(Predicted)
color :White to off-white
Density :1.335
storage temp. :Store at -20°C
solubility :≥32.4 mg/mL in DMSO; ≥16.53 mg/mL in H2O with ultrasonic; ≥3.16 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :9.33±0.30(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||
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Description
A-966492 effectively inhibits PARP-1 with an EC50 of 1 nM and a Ki value of 1 nM. When it acts on PARP-2, the Ki value is 1.5 nM. It has excellent efficacy on PARP enzyme, especially on C41 cells. A-966492 significantly enhanced the effect of TMZ in a dose-dependent manner.Related product price
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