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(-)-BETA-HYDRASTINE

(-)-BETA-HYDRASTINE Structure
  • ₹0
  • Product name: (-)-BETA-HYDRASTINE
  • CAS: 118-08-1
  • MF: C21H21NO6
  • MW: 383.39
  • EINECS:204-233-0
  • MDL Number:MFCD00152561
  • Synonyms:HYDRASTINE, (-)-B-(P) (AHP Verified);HYDRASTINE, (-)-B-(P);Hydrastine (base and/or unspecified salts);(1R,9S)-(-)-β-Hydrastine;(3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one;[R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one;(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone;[S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :132℃
alpha :D20 -50° (c = 0.3 in abs alc)
Boiling point :510.32°C (rough estimate)
Density :1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index :1.5614 (estimate)
storage temp. :−20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml
form :A crystalline solid
pka :7.8(at 25℃)
color :White to light yellow
Water Solubility :30mg/L(20 ºC)
CAS DataBase Reference :118-08-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd
Hangzhou FandaChem Co.,Ltd.
Chengdu Biopurify Phytochemicals Ltd.
Shaanxi Pioneer Biotech Co., Ltd .
Career Henan Chemica Co
Shaanxi Didu New Materials Co. Ltd
Hangzhou MolCore BioPharmatech Co.,Ltd.
LEAPCHEM CO., LTD. Shanghai Taopu Industrial Co., LTD