Bardoxolone methyl
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- Product name: Bardoxolone methyl
- CAS: 218600-53-4
- MF: C32H43NO4
- MW: 505.69
- EINECS:606-850-4
- MDL Number:MFCD11983137
- Synonyms:NSC 713200;Bardoxolone Me ester;Bardoxolone Methyl (RTA 402);Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester;TP-155;Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester;2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester;(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
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Properties
Melting point :215-223°C
Boiling point :600.8±55.0 °C(Predicted)
Density :1.15
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
color :White to Light Brown
InChIKey :WPTTVJLTNAWYAO-KPOXMGGZSA-N
SMILES :C1(=O)[C@@]([C@]2([C@](C)(C=C1C#N)C1[C@@]([C@]3([C@@](C(=O)C=1)([H])[C@]1([C@@](CC[C@](C1)(C)C)(C(OC)=O)CC3)[H])C)(C)CC2)[H])(C)C
CAS DataBase Reference :218600-53-4
Boiling point :600.8±55.0 °C(Predicted)
Density :1.15
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
color :White to Light Brown
InChIKey :WPTTVJLTNAWYAO-KPOXMGGZSA-N
SMILES :C1(=O)[C@@]([C@]2([C@](C)(C=C1C#N)C1[C@@]([C@]3([C@@](C(=O)C=1)([H])[C@]1([C@@](CC[C@](C1)(C)C)(C(OC)=O)CC3)[H])C)(C)CC2)[H])(C)C
CAS DataBase Reference :218600-53-4
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The synthetic oleanane triterpenoid CDDO is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.11 nM. It induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells through inhibition of IκBα kinase/NF-κB signaling. CDDO methyl ester has potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice and in Leprdb/db mice and triggering AMP-activated protein kinase and LKB1 activation in muscle and liver.Related product price
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