CILAZAPRIL
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- Product name: CILAZAPRIL
- CAS: 92077-78-6
- MF: C22H31N3O5.H2O
- MW: 435.51
- EINECS:200-258-5
- MDL Number:MFCD01692810
- Synonyms:Initiss;Justor;Vascase;9[[1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6HPYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID;CILAZAPRIL EPC(;CILAZAPRIL EPC(CRM STANDARD);CILAZAPRIL IMPURITY A1,1-DIMETHYLETHYL(1S,9S)-9-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]-10-OXO-OCTAHYDRO-6H-PYRIDAZINO[1,2A][1,2]DIAZEPINE-1-CABOXYLATE EPC;[1S-[1α，9α(R^<*>^)]]-9-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1，2-α][1，2]diazepine-1-carboxylic acid monohydrate
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Properties
Melting point :98° (dec)
alpha :D20 -62.51° (c = 1% in ethanol)
storage temp. :Store at -20°C
solubility :Slightly soluble in water, freely soluble in methanol and in methylene chloride.
pka :pKa1 3.3; pKa2 6.4(at 25℃)
form :Solid
color :White to off-white
alpha :D20 -62.51° (c = 1% in ethanol)
storage temp. :Store at -20°C
solubility :Slightly soluble in water, freely soluble in methanol and in methylene chloride.
pka :pKa1 3.3; pKa2 6.4(at 25℃)
form :Solid
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Cilazapril is a new ACE inhibitor useful in the management of mild to moderate hypertension. Orally administered cilazapril is a prodrug which is de-esterified to its active diacid metabolite cilazprilat. Compared with enalapril and captopril, cilazapril is more potent and longer lasting.More related product prices
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