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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >DNA damage >DNA / RNA Synthesis inhibitors >CX-5461

CX-5461

CX-5461 Structure
  • ₹23559.99
  • Product name: CX-5461
  • CAS: 1138549-36-6
  • MF: C27H27N7O2S
  • MW: 513.61
  • EINECS:
  • MDL Number:MFCD21609261
  • Synonyms:CX-5461;2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-Methylpyrazin-2-yl)Methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxaMide;2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide;CX-5461/CX5461;2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-N-[(5-Methyl-2-pyrazinyl)Methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]napht;5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-;CX-5461;CX 5461;CX5461;CX-5461 500MG
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.09265
  • Product descriptionRNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem A cell-permeable, selective inhibitor of RNA polymerase I-mediated pre-rRNA transcription (IC?? = 142 nM in HCT-116 cells).
  • Packaging10MG
  • Price₹23559.99
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.09265 RNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem A cell-permeable, selective inhibitor of RNA polymerase I-mediated pre-rRNA transcription (IC?? = 142 nM in HCT-116 cells). 10MG ₹23559.99 2022-06-14 Buy

Properties

Boiling point :739.9±60.0 °C(Predicted)
Density :1.45
storage temp. :+2C to +8C
solubility :insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form :Light beige powder
pka :8.53±0.20(Predicted)
color :White to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT-116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25μM), DNA replication, or protein translation. At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.

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