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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Alkylating antineoplastic >Chlorambucil

Chlorambucil

Chlorambucil Structure
  • ₹5600 - ₹63153.05
  • Product name: Chlorambucil
  • CAS: 305-03-3
  • MF: C14H19Cl2NO2
  • MW: 304.21
  • EINECS:206-162-0
  • MDL Number:MFCD00021783
  • Synonyms:CHLORAMBUCIL;4-(p-N,N-Di-(beta-chloroethyl)aminophenyl)butyric acid;CHLOCAMBUCIL;Chloroambucil=Chloroaminophene=Amboclorin=Leukeran;4-((P-BIS-(B-CHLOROETHYL)AMINO)PHENYL)BUTYRIC ACID;4(p-bis(beta-chloroethyl)aminophenyl)butyricacid ;4-[Bis(2-chioroethyl)amino]benzenebutanoicacid ;4-(4-[bis(2-chloroethyl)amino]phenyl)butyric acid
4 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 200MG
  • 1G
  • 10G
  • ManufacturerTCI Chemicals (India)
  • Product numberC2939
  • Product descriptionChlorambucil min. 98.0 %
  • Packaging200MG
  • Price₹5600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2939
  • Product descriptionChlorambucil min. 98.0 %
  • Packaging1G
  • Price₹16200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0253
  • Product descriptionChlorambucil
  • Packaging1G
  • Price₹8129.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0253
  • Product descriptionChlorambucil
  • Packaging10G
  • Price₹63153.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2939 Chlorambucil min. 98.0 % 200MG ₹5600 2022-05-26 Buy
TCI Chemicals (India) C2939 Chlorambucil min. 98.0 % 1G ₹16200 2022-05-26 Buy
Sigma-Aldrich(India) C0253 Chlorambucil 1G ₹8129.58 2022-06-14 Buy
Sigma-Aldrich(India) C0253 Chlorambucil 10G ₹63153.05 2022-06-14 Buy

Properties

Melting point :65-70 °C
Boiling point :460.1±40.0 °C(Predicted)
Density :1.2486 (rough estimate)
refractive index :1.6070 (estimate)
storage temp. :2-8°C
solubility :Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
pka :pKa ~1.3(H2O) (Uncertain)
form :Solid
color :White to Light yellow
Water Solubility :<0.01 g/100 mL at 22 ºC
λmax :588nm(DMSO aq.)(lit.)
Merck :14,2073
BRN :999011
BCS Class :3/1
Stability :Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
InChIKey :JCKYGMPEJWAADB-UHFFFAOYSA-N
CAS DataBase Reference :305-03-3(CAS DataBase Reference)
IARC :1 (Vol. 26, Sup 7, 100A) 2012
NIST Chemistry Reference :Chlorambucil(305-03-3)
EPA Substance Registry System :Chlorambucil (305-03-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. It can be covalently coupled to monoclonal anticarcinombryonic antigen.

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