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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Diflunisal

Diflunisal

Diflunisal Structure
  • ₹7296.05
  • Product name: Diflunisal
  • CAS: 22494-42-4
  • MF: C13H8F2O3
  • MW: 250.2
  • EINECS:245-034-9
  • MDL Number:MFCD00057834
  • Synonyms:DIFLUSINAL;LABOTEST-BB LT00771921;2',4'-DIFLUORO-4-HYDROXY[1,1'-BIPHENYL]-3-CARBOXYLIC ACID;2',4'-DIFLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID;5-[2,4-DIFLUOROPHENYL]SALICYLIC ACID;[1,1'-Biphenyl]-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-;1’-biphenyl)-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-( ;1’-biphenyl]-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-[
Price1 Properties Safety Information Description
1 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product numberD3281
  • Product descriptionDiflunisal analytical standard
  • Packaging5G
  • Price₹7296.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) D3281 Diflunisal analytical standard 5G ₹7296.05 2022-06-14 Buy

Properties

Melting point :207-209?C
Boiling point :386.9±42.0 °C(Predicted)
Density :1.3505 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Practically insoluble in water, soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
form :Solid
pka :pKa 3.3 (H2O I=0.1) (Uncertain)
color :White
Water Solubility :6.186mg/L(24.99 ºC)
CAS DataBase Reference :22494-42-4(CAS DataBase Reference)
NIST Chemistry Reference :Diflunisal(22494-42-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX-1 (IC50 = 113 μM) and COX-2 (IC50s = 8.2 and 134 μM for human whole blood assay and human-modified whole blood assays, respectively). Peak plasma levels are achieved within two hours, with little metabolism before excretion in the urine. The terminal plasma half-life is approximately eight hours.

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Suppliers and manufacturers

Aarti Industries Limited (AIL) Rivashaa Agrotech Biopharma Pvt. Ltd. Apicore Pharmaceuticals Pvt Ltd Cohance Lifesciences (Previously RA Chem Pharma Ltd) TCI Chemicals (India) Pvt. Ltd. AARTI INDUSTRIES LTD RA CHEM PHARMA LTD MYLAN API US LLC SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd