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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >Microtubule Associated inhibitors >Epothilone A

Epothilone A

Epothilone A Structure
  • ₹24583.58
  • Product name: Epothilone A
  • CAS: 152044-53-6
  • MF: C26H39NO6S
  • MW: 493.66
  • EINECS:
  • MDL Number:MFCD26960884
  • Synonyms:4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-;Epothilone-S;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;Epothile;4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetraMethyl-3- [(1E)-1-Methy;Ixabepilone Impurity 5 (Epothilone A);(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone A
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10μG
  • ManufacturerSigma-Aldrich(India)
  • Product numberE3656
  • Product description(−)-Epothilone A from Sorangium cellulosum, >95% (HPLC), solid
  • Packaging10μG
  • Price₹24583.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) E3656 (−)-Epothilone A from Sorangium cellulosum, >95% (HPLC), solid 10μG ₹24583.58 2022-06-14 Buy

Properties

Melting point :95℃
alpha :D21 -47.1° (c = 1.0 in methanol)
Boiling point :683.3±55.0 °C(Predicted)
Density :1.143
storage temp. :-20°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
pka :13.57±0.70(Predicted)
form :solid
color :White to Off-White
Stability :Stable under recommended storage conditions., Stable Under Recommended Storage C

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Epothilone A (Epo A) is a biologically active macrolide produced from the fermentation of the soil bacteria S. cellulosum that was discovered as a potent antimicrotubule agent. In competition assays, epo A binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel to β-tubulin (IC50s = 2.3 and 3.6 μM, respectively). Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 μM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B .

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