GSK5959
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- ₹0
- Product name: GSK5959
- CAS: 901245-65-6
- MF: C22H26N4O3
- MW: 394.47
- EINECS:
- MDL Number:MFCD14744183
- Synonyms:GSK5959;Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-;CS-1636;GSK-5959;GSK5959;N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide;BRPF1-IN-3;BRPF3,GSK5959,bromodomain,Inhibitor,inhibit,BRD1,BRPF1,Epigenetic Reader Domain,GSK-5959,GSK 5959,BRPF2,epigenetics;N-(1,3-dimethyl-2-oxo-6-(piperidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Boiling point :527.3±50.0 °C(Predicted)
Density :1.263±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 13 mg/mL (32.96 mM; Need ultrasonic and warming)
form :Powder
pka :13.06±0.20(Predicted)
color :Light yellow to yellow
Density :1.263±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 13 mg/mL (32.96 mM; Need ultrasonic and warming)
form :Powder
pka :13.06±0.20(Predicted)
color :Light yellow to yellow
Safety Information
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Description
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system. GSK5959 is a potent, cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM). It exhibits greater than 100-fold selectivity for the BRPF1 bromodomain over a panel of 35 other bromodomains. GSK5959 disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Career Henan Chemica Co
InvivoChem
Nanjing Doge Biomedical Technology Co., Ltd
ShenZhen Trendseen Biological Technology Co.,Ltd.
LEAPCHEM CO., LTD.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Amadis Chemical Company Limited