ROR gamma-t-IN-1
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- ₹0
- Product name: ROR gamma-t-IN-1
- CAS: 1426802-50-7
- MF: C23H18Cl2F3NO4S
- MW: 532.36
- EINECS:
- MDL Number:MFCD28902182
- Synonyms:ROR gamma-t-IN-1;GSK805;GSK805 (GSK-805);N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one;Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-;N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide;N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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Properties
Boiling point :617.1±55.0 °C(Predicted)
Density :1.434±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM) form :A crystalline solid
pka :12.33±0.70(Predicted)
color :White to off-white
Density :1.434±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM) form :A crystalline solid
pka :12.33±0.70(Predicted)
color :White to off-white
Safety Information
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Description
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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