GSK872
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- ₹0
- Product name: GSK872
- CAS: 1346546-69-7
- MF: C19H17N3O2S2
- MW: 383.49
- EINECS:
- MDL Number:MFCD30481302
- Synonyms:GSK872;N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine;N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine HCl salt;N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine HCL SALT // GSK-872 HCL;4-Quinolinamine, N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-;GSK'872 (GSK2399872A);GSK'872;GSK872;GSK2399872A;GSK2399872A
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Properties
Boiling point :625.7±55.0 °C(Predicted)
Density :1.395±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :5.53±0.49(Predicted)
form :solid
color :Off-White or pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Density :1.395±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :5.53±0.49(Predicted)
form :solid
color :Off-White or pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
GSK 872 (CAS 1346546-69-7) is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 μM).2More related product prices
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