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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >Raf inhibitors >GW5074

GW5074

GW5074 Structure
  • ₹16605.55 - ₹49795
  • Product name: GW5074
  • CAS: 220904-83-6
  • MF: C15H8Br2INO2
  • MW: 520.94
  • EINECS:
  • MDL Number:MFCD09971042
  • Synonyms:RAF1 KINASE INHIBITOR I;(3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE;5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE;3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE;3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE;GW5074;2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-;3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberG6416
  • Product descriptionGW5074 powder
  • Packaging5MG
  • Price₹16605.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number553008
  • Product descriptionRaf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is
  • Packaging1MG
  • Price₹19380
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG6416
  • Product descriptionGW5074 powder
  • Packaging25MG
  • Price₹49795
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) G6416 GW5074 powder 5MG ₹16605.55 2022-06-14 Buy
Sigma-Aldrich(India) 553008 Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is 1MG ₹19380 2022-06-14 Buy
Sigma-Aldrich(India) G6416 GW5074 powder 25MG ₹49795 2022-06-14 Buy

Properties

Boiling point :561.4±50.0 °C(Predicted)
Density :2.248±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble
form :solid
pka :5.86±0.25(Predicted)
color :yellow to orange-brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :LMXYVLFTZRPNRV-XCVCLJGOSA-N
CAS DataBase Reference :220904-83-6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

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