GW441756
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- ₹0
- Product name: GW441756
- CAS: 504433-23-2
- MF: C17H13N3O
- MW: 275.3
- EINECS:
- MDL Number:MFCD08703104
- Synonyms:1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE;GW 441756;Gw;2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-;(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Boiling point :568.0±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :Soluble in DMSO (up to 5 mg/ml).
pka :11.04±0.20(Predicted)
form :solid
color :Orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :Soluble in DMSO (up to 5 mg/ml).
pka :11.04±0.20(Predicted)
form :solid
color :Orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
Symbol(GHS): |
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Description
The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis. GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM). It displays >100-fold selectivity over a panel of related kinases. GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-β protein precursor cleavage in neuroglioma cells.More related product prices
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