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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >PPAR antagonist >GW9662

GW9662

GW9662 Structure
  • ₹8310 - ₹33100
  • Product name: GW9662
  • CAS: 22978-25-2
  • MF: C13H9ClN2O3
  • MW: 276.68
  • EINECS:636-590-7
  • MDL Number:MFCD01215270
  • Synonyms:GW9662, >=98%;2-CHLORO-5-NITROBENZANILIDE;GW9662;TIMTEC-BB SBB006523;2-Chloro-5-nitro-N-4-phenylbenzamide;BenzaMide,2-chloro-5-nitro-N-phenyl-;N-[(2-chloro-5-nitrophenyl)-phenylmethylidene]hydroxylamine;2-Chloro-5-nitrobenzanilide 97%
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 25G
  • ManufacturerSigma-Aldrich(India)
  • Product numberM6191
  • Product descriptionGW9662 >98% (HPLC)
  • Packaging5MG
  • Price₹8310
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number642355
  • Product description2-Chloro-5-nitrobenzanilide 97%
  • Packaging25G
  • Price₹11550.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM6191
  • Product descriptionGW9662 >98% (HPLC)
  • Packaging25MG
  • Price₹33100
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) M6191 GW9662 >98% (HPLC) 5MG ₹8310 2022-06-14 Buy
Sigma-Aldrich(India) 642355 2-Chloro-5-nitrobenzanilide 97% 25G ₹11550.28 2022-06-14 Buy
Sigma-Aldrich(India) M6191 GW9662 >98% (HPLC) 25MG ₹33100 2022-06-14 Buy

Properties

Melting point :158-159 °C (lit.)
Boiling point :360.9±32.0 °C(Predicted)
Density :1.440±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 26 mg/mL, soluble
form :solid
pka :11.77±0.70(Predicted)
color :white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :DNTSIBUQMRRYIU-UHFFFAOYSA-N
CAS DataBase Reference :22978-25-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 μM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.

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