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ChemicalBook > Product Catalogue >Biochemical Engineering >Natural Products >Galanthamine

Galanthamine

Galanthamine Structure
  • ₹0
  • Product name: Galanthamine
  • CAS: 357-70-0
  • MF: C17H21NO3
  • MW: 287.35
  • EINECS:609-175-3
  • MDL Number:MFCD00867189
  • Synonyms:GALANTHAMINE;GALANTHAMINE HYDROCHLORIDE;(4as,6r,8as)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6h-benzofuro[3a,3,2-ef][2]benzazepin-6-ol;6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS-(4aalpha,6beta,8aR*))-;6h-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methox ;Jilkon;Lycoremin;Lycoremine
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :119-1210C
alpha :D20 -118.8° (c = 1.378 in ethanol)
Boiling point :429.65°C (rough estimate)
Density :1.0662 (rough estimate)
refractive index :1.5022 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :≥14.37 mg/mL in DMSO; ≥14.43 mg/mL in H2O with gentle warming; ≥45 mg/mL in EtOH with gentle warming
form :Powder
pka :pKa 8.32 (Uncertain)
color :White to off-white
CAS DataBase Reference :357-70-0(CAS DataBase Reference)
NIST Chemistry Reference :Galantamin(357-70-0)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P363 Wash contaminated clothing before reuse.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Galantamine is an alkaloid originally isolated from the bulbs and flowers of various Galanthus species. It allosterically potentiates nicotinic acetylcholine receptors, as well as inhibits acetylcholinesterase (IC50 = 636-2010 nM), thereby promoting acetylcholine activity in the brain. Galantamine has been used in the clinical treatment of vascular dementia and Alzheimer’s disease symptoms and as a nootropic for other cognitive impairments.

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