IM-12
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- ₹12795.15
- Product name: IM-12
- CAS: 1129669-05-1
- MF: C22H20FN3O2
- MW: 377.41
- EINECS:
- MDL Number:MFCD20527313
- Synonyms:IM-12;3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione IM-12;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;CS-1819;CS-2144;The GSK3β Inhibitor XIX
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0084
- Product descriptionIM-12 ≥98% (HPLC)
- Packaging5MG
- Price₹12795.15
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0084 | IM-12 ≥98% (HPLC) | 5MG | ₹12795.15 | 2022-06-14 | Buy |
Properties
Melting point :187 °C
Boiling point :600.2±55.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥9mg/mL
form :powder
pka :16.77±0.30(Predicted)
color :yellow-orange
Boiling point :600.2±55.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥9mg/mL
form :powder
pka :16.77±0.30(Predicted)
color :yellow-orange
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.More related product prices
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