5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
![5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime Structure](/CAS2/GIF/405554-55-4.gif)
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- ₹15544.7 - ₹62633.45
- Product name: 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
- CAS: 405554-55-4
- MF: C27H27N5O2
- MW: 453.54
- EINECS:
- MDL Number:MFCD16038645
- Synonyms:5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime;1H-Inden-1-one, 5-[2-[4-[2-(diMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro-, oxiMe;GSK 2118436(SB 590885);SB590885(GSK2118436);5-[2-[4-[2-(DiMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro-1H-inden-1-on;(E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime;SB590885;GSK 2118436
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0501
- Product descriptionSB-590885 ≥98% (HPLC)
- Packaging25MG
- Price₹62633.45
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0501
- Product descriptionSB-590885 ≥98% (HPLC)
- Packaging5MG
- Price₹15544.7
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0501 | SB-590885 ≥98% (HPLC) | 25MG | ₹62633.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0501 | SB-590885 ≥98% (HPLC) | 5MG | ₹15544.7 | 2022-06-14 | Buy |
Properties
Density :1.27
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChIKey :MLSAQOINCGAULQ-QLTSDVKISA-N
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChIKey :MLSAQOINCGAULQ-QLTSDVKISA-N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM). It less effectively inhibits c-Raf (Ki = 1.72 nM) and has little effect at 46 other kinases. SB-590885 blocks activation of ERK1/2 and anchorage-independent cell proliferation of melanoma cells with either wild type or V600E B-Raf at nanomolar concentrations. Melanoma cells expressing the B-RafV600E mutation can drive invasion through alternative pathways in the presence of SB-590885, suggesting that combination therapy is needed to completely block cell invasion. SB-590885 has also been used to study the role of B-Raf in cerebral ischemia.Related product price
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Suppliers and manufacturers
career henan chemical co
![5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime](https://img.chemicalbook.com/ProductImageEN/2018-12/small/0d29a12c-2ca6-431a-b0b8-b91eca49647d.png)
A.J Chemicals
Capot Chemical Co.,Ltd.
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Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
₹2.00 /1kg
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime CAS:405554-55-4
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime CAS:405554-55-4