Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >5-HT Receptor Antagonists >Sb-742457

Sb-742457

Sb-742457 Structure
  • ₹0
  • Product name: Sb-742457
  • CAS: 607742-69-8
  • MF: C19H19N3O2S
  • MW: 353.44
  • EINECS:
  • MDL Number:MFCD12828872
  • Synonyms:Gsk 742457;Sb 742457;Sb-742457;3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline;SB 742457/GSK 742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-;SB742457:Intepirdine;Intepirdine(SB742457)
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :608.3±45.0 °C(Predicted)
Density :1.292
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :8?+-.0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.

More related product prices

Lurasidone hydrochloride Piperazine SB 225002 SB 743921 SB 203580 SB-705498 472981-92-3 356559-20-1 405554-55-4 SB 431542 SB 202190 SB 415286 SB 242084 (hydrochloride) MMP-2/MMP-9 INHIBITOR IV SB216763 Ispinesib 694433-59-5 SB 204741 SB-649868 GSK-CXCR2

Related product price

Suppliers and manufacturers

career henan chemical co
Sb-742457
₹2.00 /1kg
Sb-742457 CAS:607742-69-8
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.