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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >GPCR & G Protein >CXCR antagonist >SB 225002

SB 225002

SB 225002 Structure
  • ₹7200 - ₹46374.3
  • Product name: SB 225002
  • CAS: 182498-32-4
  • MF: C13H10BrN3O4
  • MW: 352.14
  • EINECS:
  • MDL Number:MFCD00954637
  • Synonyms:SB 225002;N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA;N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA;1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea;SB 225002 - CAS 182498-32-4 - Calbiochem;SB-225002;SB 225002;Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-;SB 225002 USP/EP/BP
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB6055
  • Product descriptionSB 225002
  • Packaging10MG
  • Price₹7200
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB6055
  • Product descriptionSB 225002
  • Packaging50MG
  • Price₹22500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0716
  • Product descriptionSB225002 ≥98% (HPLC)
  • Packaging5MG
  • Price₹11387.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number559405
  • Product descriptionSB 225002 - CAS 182498-32-4 - Calbiochem A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC?? = 22 nM for the inhibition of 12?I-IL-8 binding
  • Packaging1MG
  • Price₹13710
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0716
  • Product descriptionSB225002 ≥98% (HPLC)
  • Packaging25MG
  • Price₹46374.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B6055 SB 225002 10MG ₹7200 2022-05-26 Buy
TCI Chemicals (India) B6055 SB 225002 50MG ₹22500 2022-05-26 Buy
Sigma-Aldrich(India) SML0716 SB225002 ≥98% (HPLC) 5MG ₹11387.9 2022-06-14 Buy
Sigma-Aldrich(India) 559405 SB 225002 - CAS 182498-32-4 - Calbiochem A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC?? = 22 nM for the inhibition of 12?I-IL-8 binding 1MG ₹13710 2022-06-14 Buy
Sigma-Aldrich(India) SML0716 SB225002 ≥98% (HPLC) 25MG ₹46374.3 2022-06-14 Buy

Properties

Boiling point :401.6±45.0 °C(Predicted)
Density :1.793±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble to 100mM in DMSO and to 50mM in ethanol
form :Yellow solid
pka :5.29±0.10(Predicted)
color :white to beige
Sensitive :Moisture Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :MQBZVUNNWUIPMK-UHFFFAOYSA-N
CAS DataBase Reference :182498-32-4

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.

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