JAK3 Inhibitor
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- ₹6200 - ₹28660
- Product name: JAK3 Inhibitor
- CAS: 211555-04-3
- MF: C16H14BrN3O3
- MW: 376.2
- EINECS:809-014-9
- MDL Number:MFCD02179366
- Synonyms:JAK3 Inhibitor;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem;CS-1516;whi-p154cas
3 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 50MG
- ManufacturerTCI Chemicals (India)
- Product numberW0013
- Product descriptionWHI-P154
- Packaging10MG
- Price₹6200
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberW0013
- Product descriptionWHI-P154
- Packaging50MG
- Price₹17200
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number420104
- Product descriptionJAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily use
- Packaging5MG
- Price₹28660
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | W0013 | WHI-P154 | 10MG | ₹6200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | W0013 | WHI-P154 | 50MG | ₹17200 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | 420104 | JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily use | 5MG | ₹28660 | 2022-06-14 | Buy |
Properties
Melting point :230 °C
Boiling point :470.3±45.0 °C(Predicted)
Density :1.576±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :8.57±0.31(Predicted)
form :powder
color :white to brown
InChIKey :CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference :211555-04-3
Boiling point :470.3±45.0 °C(Predicted)
Density :1.576±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :8.57±0.31(Predicted)
form :powder
color :white to brown
InChIKey :CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference :211555-04-3
Safety Information
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Description
Janus-associated kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription. JAK3 is abundantly expressed in normal lymphoid cells as well as human lymphoblastic and myeloblastic leukemia cells. WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.Related product price
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