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ChemicalBook > Product Catalogue >API >Antiallergic drugs >Antihistamines >Meclizine dihydrochloride

Meclizine dihydrochloride

Meclizine dihydrochloride Structure
  • ₹7700 - ₹11710.5
  • Product name: Meclizine dihydrochloride
  • CAS: 1104-22-9
  • MF: C25H29Cl3N2
  • MW: 463.87
  • EINECS:214-164-8
  • MDL Number:MFCD00058199
  • Synonyms:Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride;Meclozine Hcl;1-((4-Chlorophenyl)(phenyl)Methyl)-4-(3-Methylbenzyl)piperazine dihydrochloride;Meclizine 2HCl;Piperazine,1-[(4-chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]-, hydrochloride(1:2);1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine,hydrochloride (1:2);1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-piperazine dihydrochloride;1-p-chlorbenzhydryl-m-methylbenzylpiperazinedihydrochloride
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberM2755
  • Product descriptionMeclizine Dihydrochloride
  • Packaging5G
  • Price₹7700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM2755
  • Product descriptionMeclizine Dihydrochloride
  • Packaging25G
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0950
  • Product descriptionMeclizine dihydrochloride ≥97% (HPLC)
  • Packaging50MG
  • Price₹11710.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) M2755 Meclizine Dihydrochloride 5G ₹7700 2022-05-26 Buy
TCI Chemicals (India) M2755 Meclizine Dihydrochloride 25G ₹9800 2022-05-26 Buy
Sigma-Aldrich(India) SML0950 Meclizine dihydrochloride ≥97% (HPLC) 50MG ₹11710.5 2022-06-14 Buy

Properties

Melting point :210.0 to 214.0 °C
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
form :powder
color :white to beige
CAS DataBase Reference :1104-22-9(CAS DataBase Reference)
EPA Substance Registry System :Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Meclizine is an antagonist of the histamine H1 receptor (Ki = 250 nM). Unlike some antihistamines, it has low affinity for muscarinic receptors (Ki = 3.6 nM). Meclizine is also a weak agonist of pregnane X receptor (EC50 > 10 μM). Because of its actions on the H1 receptor, meclizine reduces nausea, dizziness, and motion sickness. The effects of this compound on early development are diverse.

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Suppliers and manufacturers

Viyash Life Sciences Pvt Ltd Calyx Chemicals and Pharmaceuticals Ltd Hetero Drugs Limited J.B. Chemicals Pharmaceuticals Ltd. Fleming Laboratories Ltd DK Pharmachem Pvt Ltd Ralington Pharma Cohance Lifesciences (Previously RA Chem Pharma Ltd) Sri Krishna Pharmaceuticals Ltd SRIKEM LABORATORIES PVT LTD