NU 2058
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- ₹7200 - ₹17612.28
- Product name: NU 2058
- CAS: 161058-83-9
- MF: C12H17N5O
- MW: 247.3
- EINECS:
- MDL Number:MFCD05664734
- Synonyms:6-(Cyclohexylmethoxy)-9H-purin-2-amine;2-aMino-6-purine;2-aMino-6-[(cyclohexylMethyl)oxy]purine;2-Amino-6-(cyclohexylmethoxy)purine;CS-2601;NU 2058;NU-2058;NU2058;NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE;NU2058>
3 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 20MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberN0958
- Product descriptionNU 2058
- Packaging20MG
- Price₹7200
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberN0958
- Product descriptionNU 2058
- Packaging100MG
- Price₹14400
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberN4286
- Product descriptionNU2058 >98% (HPLC)
- Packaging5MG
- Price₹17612.28
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | N0958 | NU 2058 | 20MG | ₹7200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0958 | NU 2058 | 100MG | ₹14400 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | N4286 | NU2058 >98% (HPLC) | 5MG | ₹17612.28 | 2022-06-14 | Buy |
Properties
Melting point :199°C(lit.)
Boiling point :424.8±55.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: 22 mg/mL
form :powder to crystal
pka :7.36±0.20(Predicted)
color :white
λmax :281nm(MeOH)(lit.)
InChIKey :MWGXGTJJAOZBNW-UHFFFAOYSA-N
Boiling point :424.8±55.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: 22 mg/mL
form :powder to crystal
pka :7.36±0.20(Predicted)
color :white
λmax :281nm(MeOH)(lit.)
InChIKey :MWGXGTJJAOZBNW-UHFFFAOYSA-N
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
NU2058, O(6)-Cyclohexylmethylguanine, has displayed the capacity to competitively inhibit CDK1 and CDK2 with respect to ATP and has also been shown to inhibit Topo II ATPase activity. Studies suggest that NU2058 also modifies p53-dependent transcription and interrupts the cell cycle causing cell growth arrest. NU2058 demonstrates the ability to alter the transport of platinum-based compounds via an increase in DNA adducts, which causes an increase in intracellular platinum levels. Further experiments reveal that growth inhibition caused by NU2058 is correlated to an increase in p27 levels, a decrease in early gene expression and CDK2 activity, as well as G1 cell cycle arrest. NU2058 is an inhibitor of cyclin A and cyclin B.More related product prices
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