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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >CDK inhibitors >Roscovitine

Roscovitine

Roscovitine Structure
  • ₹5880 - ₹38352.98
  • Product name: Roscovitine
  • CAS: 186692-46-6
  • MF: C19H26N6O
  • MW: 354.45
  • EINECS:
  • MDL Number:MFCD02266401
  • Synonyms:2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine;(2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol;2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE;2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE;6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE;ROSCOVITINE;(R)-ROSCOVITINE;(R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number557360
  • Product descriptionRoscovitine - CAS 186692-46-6 - Calbiochem A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater e
  • Packaging1MG
  • Price₹5880
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR7772
  • Product descriptionRoscovitine ≥98% (TLC)
  • Packaging1MG
  • Price₹11463.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number557360
  • Product descriptionRoscovitine - CAS 186692-46-6 - Calbiochem A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater e
  • Packaging5MG
  • Price₹29990
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR7772
  • Product descriptionRoscovitine ≥98% (TLC)
  • Packaging5MG
  • Price₹38352.98
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 557360 Roscovitine - CAS 186692-46-6 - Calbiochem A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater e 1MG ₹5880 2022-06-14 Buy
Sigma-Aldrich(India) R7772 Roscovitine ≥98% (TLC) 1MG ₹11463.68 2022-06-14 Buy
Sigma-Aldrich(India) 557360 Roscovitine - CAS 186692-46-6 - Calbiochem A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater e 5MG ₹29990 2022-06-14 Buy
Sigma-Aldrich(India) R7772 Roscovitine ≥98% (TLC) 5MG ₹38352.98 2022-06-14 Buy

Properties

Melting point :106～107℃
Boiling point :577.5±60.0 °C(Predicted)
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form :White to off-white solid
pka :14.56±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :BTIHMVBBUGXLCJ-OAHLLOKOSA-N
CAS DataBase Reference :186692-46-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases which suppresses the proliferation of mammalian cell lines. Selective for Cdk1/cyclin B kinase (IC50=450nM), Cdk2 (IC50=700nM) and Cdk5/p35 (IC50=160nM). Roscovitine is more potent than olomoucine (sc-201526). It inhibits M phase promoting factor kinase activity and affects calcium channel gating. Roscovitine reversibly inhibits the transition from prophase to metaphase at micromolar concentrations in starfish oocytes and sea urchin embryos. It also inhibits in vitro M-phase-promoting factor activity and in vitro DNA synthesis in Xenopus egg extracts. A recent study shows that roscovitine inhibits Cdk5 kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dictyostelium discoideum, without affecting the expression of Cdk5 protein during axenic growth. Roscovitine is an inhibitor of Cdk7, cyclin B, cyclin E, cyclin A, cyclin H, cdc2 and p53.

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Suppliers and manufacturers

Hebei Duling International Trade Co. LTD
ROSCOVITINE
₹15.00 /100kg
ROSCOVITINE CAS:186692-46-6
career henan chemical co
ROSCOVITINE
₹1.00 /1KG
ROSCOVITINE CAS:186692-46-6
CLEARSYNTH LABS LTD. A.J Chemicals
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Shanghai Gubang New Materail Technology Co. LTD
Dideu Industries Group Limited