Onalespib
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- ₹0
- Product name: Onalespib
- CAS: 912999-49-6
- MF: C24H31N3O3
- MW: 409.52
- EINECS:
- MDL Number:MFCD18633198
- Synonyms:(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone;AT-13387;4-({5-[(4-Methylpiperazin-1-yl)Methyl]-2,3-dihydro-1H-isoindol-2-yl}carbonyl)-6-(propan-2-yl)benzene-1,3-diol;[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone;Onalespib;Onalespib (AT13387);[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone AT13387;AT13387, >=98%
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Properties
Boiling point :605.7±55.0 °C(Predicted)
Density :1.237
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form :solid
pka :8.50±0.48(Predicted)
color :White to off-white
Density :1.237
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form :solid
pka :8.50±0.48(Predicted)
color :White to off-white
Safety Information
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Description
Onalespib, also known as AT13387, is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models. It differs from other HSP90 inhibitors in its longer duration of target inhibition and its favorable toxicity profile in phase I studies in patients with refractory solid tumors.Related product price
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