BIIB-021
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- ₹39906 - ₹58509
- Product name: BIIB-021
- CAS: 848695-25-0
- MF: C14H15ClN6O
- MW: 318.76
- EINECS:812-781-2
- MDL Number:MFCD15528939
- Synonyms:CNF2024;9-[2-(2,2-diMethyl-propylaMino)ethyl]-8-(2-iodo-5-Methoxy-phenylsulfanyl)-9H-purin-6-ylaMine;CNF-2024EC102;9H-Purin-2-aMine, 6-chloro-9-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-;6-chloro-9-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)-9H-purin-2-aMine;BIIB-021;BIIB021/CNF2024;6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
2 prices
Selected condition：
Brand
- ottokemi
Package
- 5mg
- 10mg
- Manufacturerottokemi
- Product number B 8637
- Product descriptionBIIB 021, ≥98%
- Packaging5mg
- Price₹39906
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number B 8637
- Product descriptionBIIB 021, ≥98%
- Packaging10mg
- Price₹58509
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ottokemi | B 8637 | BIIB 021, ≥98% | 5mg | ₹39906 | 2022-05-26 | Buy |
| ottokemi | B 8637 | BIIB 021, ≥98% | 10mg | ₹58509 | 2022-05-26 | Buy |
Properties
Melting point :192-193℃
Boiling point :588.5±60.0 °C(Predicted)
Density :1.50
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :6.07±0.40(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
Boiling point :588.5±60.0 °C(Predicted)
Density :1.50
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :6.07±0.40(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
BIIB021 is a potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC50 = 38 nM), while up-regulating the expression of Hsp70 and Hsp27. It is cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft tumors. BIIB021 suppresses growth in various lymphoma cells but not in normal lymphocytes and induces apoptosis in a myelodysplastic syndrome cell line.Related product price
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