Phlorizin
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- ₹5564.05
- Product name: Phlorizin
- CAS: 60-81-1
- MF: C21H24O10
- MW: 436.41
- EINECS:200-487-1
- MDL Number:MFCD00006591
- Synonyms:1-propanone,1-(2-(beta-d-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyp ;phlorhizin ;phloridzine ;phlorizine ;phlorizoside ;1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-;4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-;Floridzin
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 100MG
- ManufacturerSigma-Aldrich(India)
- Product numberCDS000104
- Product descriptionPhlorizin hydrate AldrichCPR
- Packaging100MG
- Price₹5564.05
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | CDS000104 | Phlorizin hydrate AldrichCPR | 100MG | ₹5564.05 | 2022-06-14 | Buy |
Properties
Melting point :113-114 °C(lit.)
Boiling point :468.89°C (rough estimate)
Density :1.3178 (rough estimate)
refractive index :-54 ° (C=3.2, 95% EtOH)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :7.15±0.40(Predicted)
color :Light Yellow to Tan
Merck :14,7327
InChIKey :IOUVKUPGCMBWBT-LKLLPNDVNA-N
SMILES :C(C1C(=CC(O)=CC=1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)(=O)CCC1C=CC(O)=CC=1 |&1:9,10,11,13,15,r|
LogP :0.452 (est)
CAS DataBase Reference :60-81-1(CAS DataBase Reference)
EPA Substance Registry System :Phlorizin (60-81-1)
Boiling point :468.89°C (rough estimate)
Density :1.3178 (rough estimate)
refractive index :-54 ° (C=3.2, 95% EtOH)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :7.15±0.40(Predicted)
color :Light Yellow to Tan
Merck :14,7327
InChIKey :IOUVKUPGCMBWBT-LKLLPNDVNA-N
SMILES :C(C1C(=CC(O)=CC=1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)(=O)CCC1C=CC(O)=CC=1 |&1:9,10,11,13,15,r|
LogP :0.452 (est)
CAS DataBase Reference :60-81-1(CAS DataBase Reference)
EPA Substance Registry System :Phlorizin (60-81-1)
Safety Information
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Description
Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes. Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits the initial rate of a-methyl-D-glucopyranoside (a-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.Related product price
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₹1593-22509
Suppliers and manufacturers
TCI Chemicals (India) Pvt. Ltd.
CLEARSYNTH LABS LTD.
A.J Chemicals
Shaanxi LonierHerb Bio Technology Co Ltd
Hangzhou FandaChem Co.,Ltd.
