SIMVASTATIN, SODIUM SALT
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- Product name: SIMVASTATIN, SODIUM SALT
- CAS: 101314-97-0
- MF: C25H41NaO6
- MW: 460.59
- EINECS:
- MDL Number:MFCD04974206
- Synonyms:SIMVASTATIN HYDROXY ACID SODIUM SALT;SIMVASTATIN, SODIUM SALT;IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt;Simvastatin Impurity as Sodium Salt;Simvastati;SiMvastatin IMp. A (EP) as SodiuM Salt;sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate;Simvastatin hydroxyl acid sodium salt-d6
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Properties
Melting point :>122°C (dec.)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form :White powder solid.
color :White to Pale Beige
Stability :Hygroscopic
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form :White powder solid.
color :White to Pale Beige
Stability :Hygroscopic
Safety Information
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Description
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 μM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.More related product prices
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