THIOSTREPTON
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- ₹10670 - ₹81340.01
- Product name: THIOSTREPTON
- CAS: 1393-48-2
- MF: C72H85N19O18S5
- MW: 1664.89
- EINECS:215-734-9
- MDL Number:MFCD00135828
- Synonyms:Thiostrepton (200 mg);BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31;Thiostrepton, froM StreptoMyces sp.;x146 ;THIOSTREPTON;Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy;THIOSTREPTION;thiostrepton from streptomyces azureus
4 prices
Selected condition：
Brand
- Sigma-Aldrich
- Sigma-Aldrich(India)
Package
- 1G
- 10G
- ManufacturerSigma-Aldrich
- Product number598226
- Product descriptionThiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.
- Packaging1G
- Price₹10670
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number598226
- Product descriptionThiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.
- Packaging1G
- Price₹10670
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT8902
- Product descriptionThiostrepton from Streptomyces azureus ≥90% (HPLC)
- Packaging1G
- Price₹18250.95
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number598226
- Product descriptionThiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.
- Packaging10G
- Price₹81340.01
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 598226 | Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. | 1G | ₹10670 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 598226 | Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. | 1G | ₹10670 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T8902 | Thiostrepton from Streptomyces azureus ≥90% (HPLC) | 1G | ₹18250.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 598226 | Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. | 10G | ₹81340.01 | 2022-06-14 | Buy |
Properties
Melting point :248-257°C (dec.)
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Safety Information
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| Signal word: | Warning | |||||||
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Description
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.Related product price
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