Temocapril hydrochloride
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- Product name: Temocapril hydrochloride
- CAS: 110221-44-8
- MF: C23H28N2O5S2.ClH
- MW: 513.076
- EINECS:1312995-182-4
- MDL Number:MFCD00933433
- Synonyms:TEMOCAPRIL HYDROCHLORIDE;Acecol;CS-622;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI);1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-;Temocapril Hcl ;TemocarpileHCL;Temocarpilhydrochloride
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Properties
Melting point :196-2000C (dec)
alpha :25D +47.7° (c = 1 in DMF)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
CAS DataBase Reference :110221-44-8(CAS DataBase Reference)
alpha :25D +47.7° (c = 1 in DMF)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
CAS DataBase Reference :110221-44-8(CAS DataBase Reference)
Safety Information
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Description
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively). Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine. In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.More related product prices
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