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ChemicalBook > Product Catalogue >API >Inhibitors >Tenofovir Alafenamide

Tenofovir Alafenamide

Tenofovir Alafenamide Structure
  • ₹0
  • Product name: Tenofovir Alafenamide
  • CAS: 379270-37-8
  • MF: C21H29N6O5P
  • MW: 476.47
  • EINECS:1592732-453-0
  • MDL Number:MFCD23843796
  • Synonyms:Tenofovir Alafenamide fumarate, N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)phosphoryl]-L-alanine isopropyl ester;(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate;GS-7340/GS7340;GS-7340 Tenofovir alafenamide;tenofovir alafenamide;GS-7340-03;L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester;(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>119°C (dec.)
Boiling point :640.4±65.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :4.21±0.10(Predicted)
form :Solid
color :White to Off-White
Stability :Hygroscopic
InChIKey :LDEKQSIMHVQZJK-QTJFZWIYNA-N
SMILES :C(OC(C)C)(=O)[C@H](C)NP(CO[C@H](C)CN1C2=C(N=C1)C(N)=NC=N2)(OC1=CC=CC=C1)=O |&1:6,12,r|

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tenofovir alafenamide fumarate is an oral phosphonoamidate prodrug of the reverse transcriptase inhibitor tenofovir. It was approved by the USFDA for the treatment of chronic hepatitis B virus infection with compensated liver disease. Tenofovir alafenamide fumarate was discovered and developed by Gilead as a potentially safer form of the previously approved tenofovir disoproxil fumarate (Viread).

More related product prices

Pimecrolimus D-Alanine Isopropyl Ester HCl Thionyl chloride Tenofovir (E)-9-(prop-1-en-1-yl)-9H-purin-6-amine Tenofovir-alafenamide-hemifumarate Tenofovir disoproxil fumarate Diethyl phosphite 62062-65-1 Chloromethyl isopropyl carbonate ChloroMethyl Methyl Carbonate Chloromethyl ethyl carbonate 2491-20-5 31618-90-3

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Suppliers and manufacturers

Bulat Pharmaceutical Pvt Ltd Lupin Ltd Shilpa Medicare Limited (SML) Mangalam Drugs and Organics Ltd Aspen Biopharma Labs Pvt Ltd AUROBINDO PHARMA LTD LAURUS LABS LTD MSN LIFE SCIENCES PRIVATE LTD ALEMBIC PHARMACEUTICALS LTD MACLEODS PHARMACEUTICALS LTD