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Tolbutamide-d9

Tolbutamide-d9 Structure
  • ₹0
  • Product name: Tolbutamide-d9
  • CAS: 1219794-57-6
  • MF: C12H18N2O3S
  • MW: 270.35
  • EINECS:
  • MDL Number:
  • Synonyms:1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;Artosin-d9;Artozin-d9;Mobenol-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;Tolylsulfonylbutylurea-d9
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :108-111°C
storage temp. :Refrigerator
solubility :DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml
form :A solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.

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Suppliers and manufacturers

Pharmaffiliates Analytics and Synthetics P. Ltd CLEARSYNTH LABS LTD. Changzhou Bojia Biomedical Technology Co., Ltd. Cayman Chemical Company Shanghai Yifei Biotechnology Co. , Ltd. ChengDu SinoStandards Bio-Tech Co.,Ltd. ， Alta Scientific Co., Ltd. Shenzhen Polymeri Biochemical Technology Co., Ltd. Nanjing Haolv Biotechnology Co.,Ltd Toronto Research Chemicals