TOLAZAMIDE
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- ₹0
- Product name: TOLAZAMIDE
- CAS: 1156-19-0
- MF: C14H21N3O3S
- MW: 311.4
- EINECS:214-588-3
- MDL Number:MFCD00083504
- Synonyms:1-(hexahydro-1-azepinyl)-3-p-tolylsulfonylurea ;1-(hexahydro-1h-azepin-1-yl)-3-(p-tolylsulfonyl)-ure ;1-(hexahydro-1h-azepin-1-yl)-3-(p-tolylsulfonyl)urea ;4-(p-tolylsulfonyl)-1,1-hexamethylenesemicarbazide ;Tolazamide Solution, 100ppm;diabewas ;n-(((hexahydro-1h-azepin-1-yl)-amino)carbonyl)-4-methyl-benzenesulfonamid ;n-(p-toluenesulfonyl)-n’-hexamethyleniminourea
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Properties
Melting point :162-164°C
Boiling point :300°C (rough estimate)
Density :1.2228 (rough estimate)
refractive index :1.6740 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).
form :Solid
pka :3.6(at 25℃)
color :White to Off-White
Water Solubility :65.4mg/L(30 ºC)
CAS DataBase Reference :1156-19-0(CAS DataBase Reference)
EPA Substance Registry System :Tolazamide (1156-19-0)
Boiling point :300°C (rough estimate)
Density :1.2228 (rough estimate)
refractive index :1.6740 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).
form :Solid
pka :3.6(at 25℃)
color :White to Off-White
Water Solubility :65.4mg/L(30 ºC)
CAS DataBase Reference :1156-19-0(CAS DataBase Reference)
EPA Substance Registry System :Tolazamide (1156-19-0)
Safety Information
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Signal word: | Danger | ||||||||||||||||
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Description
Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 μM in HEK293 cells transfected with the human receptor). It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin. In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin . Formulations containing tolazamide have been used in the treatment of type 2 diabetes.Related product price
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