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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antiepileptic and anticonvulsant >Topiramate

Topiramate

Topiramate Structure
  • ₹9800 - ₹52945.08
  • Product name: Topiramate
  • CAS: 97240-79-4
  • MF: C12H21NO8S
  • MW: 339.36
  • EINECS:619-263-3
  • MDL Number:MFCD00865320
  • Synonyms:2,3:4,5-Bis-O-(1-methylethylidene)--D-fuctopyranose Sulfamate, McN-4853, RWJ-17021-000, Topamax;McN 4853, RWJ 17021, Topamax, 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-36-D-FRUCTO-PYRANOSE SULFAMATE;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-B-D-FUCTO-PYRANOSE SULFAMATE;2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose sulfamate;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-BETA-D-FUCTOPYRANOSE SULFAMATE;RWJ 17021;RWJ-17021-000
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 1G
  • 1ML
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberT2755
  • Product descriptionTopiramate
  • Packaging1G
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2755
  • Product descriptionTopiramate
  • Packaging5G
  • Price₹13700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT-039
  • Product descriptionTopiramate solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹10041.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT0575
  • Product descriptionTopiramate ≥98% (HPLC), solid
  • Packaging10MG
  • Price₹11842.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1600
  • Product descriptionTopiramate Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹12048.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT0575
  • Product descriptionTopiramate ≥98% (HPLC), solid
  • Packaging50MG
  • Price₹52945.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2755 Topiramate 1G ₹9800 2022-05-26 Buy
TCI Chemicals (India) T2755 Topiramate 5G ₹13700 2022-05-26 Buy
Sigma-Aldrich(India) T-039 Topiramate solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹10041.5 2022-06-14 Buy
Sigma-Aldrich(India) T0575 Topiramate ≥98% (HPLC), solid 10MG ₹11842.55 2022-06-14 Buy
Sigma-Aldrich(India) PHR1600 Topiramate Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹12048.23 2022-06-14 Buy
Sigma-Aldrich(India) T0575 Topiramate ≥98% (HPLC), solid 50MG ₹52945.08 2022-06-14 Buy

Properties

Melting point :125°C
alpha :D23 -34.0° (c = 0.4 in methanol)
Boiling point :438.7±55.0 °C(Predicted)
Density :1.336±0.06 g/cm3(Predicted)
Flash point :9℃
storage temp. :2-8°C
solubility :DMSO: ~44 mg/mL
form :solid
pka :9.22±0.70(Predicted)
color :white
Water Solubility :9.705g/L(temperature not stated)
Merck :14,9547
BCS Class :3
LogP :2.970 (est)
EPA Substance Registry System :.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate (97240-79-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Topiramate is a sugar sulfamate that exhibits potent anticonvulsant activity. It completely blocks seizures (ED50 = 39 mg/kg when given orally) in mice in the maximal electroshock seizure test. This effect is sustained for over eight hours. In the rotoreel test of neurotoxicity, topiramate has a peak neurotoxic dose ED50 value of 407 mg/kg in mice at one hour. It is virtually inactive against seizures caused by pentylenetetrazol, bicuculline, picrotoxin, and strychnine. It does not bind to norepinephrine, serotonin, γ-amino butyric acid, muscarinic, or dopamine receptors. The drug form of Topiramate, Topamax?, is used alone or with other medications to treat seizures associated with epilepsy and to prevent migraine headaches.

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