Trelagliptin
- ₹0
- Product name: Trelagliptin
- CAS: 865759-25-7
- MF: C18H20FN5O2
- MW: 357.38
- EINECS:1592732-453-0
- MDL Number:MFCD22572746
- Synonyms:Trelagliptin(syr472);Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-;Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile;(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile;Trelagliptin Isomer Impurity;Trelagliptin, >=98%;Trelagliptin free base;Trelagliptin
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|
Properties
Boiling point :519.0±60.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form :solid
pka :9.88±0.20(Predicted)
color :White to off-white
InChI :InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey :IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES :C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form :solid
pka :9.88±0.20(Predicted)
color :White to off-white
InChI :InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey :IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES :C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1
Safety Information
Symbol(GHS): | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Trelagliptin is a pyrimidinedione-based, long-acting inhibitor of DPP-4 (IC50 = 4 nM). It demonstrates >10,000-fold selectivity over other peptidases. Trelagliptin has been used to improve glucose tolerance and postprandial plasma insulin levels in Zucker fa/fa rats. In 2014 this compound underwent phase III clinical trials.More related product prices
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- ABT 263 475488-23-4 Entospletinib (GS-9973) Sofosbuvir Troglitazone Metformin Ibrutinib Pregabalin Afatinib (BIBW 2992) ML-323 22897-99-0 39746-00-4 (3-TRIFLUOROMETHYL-PHENOXY)-ACETIC ACID 2-Iodopropane Dimethyl methylphosphonate 39746-01-5 23735-43-5 54094-19-8Related product price
- Troglitazone
₹18889.63 - Pregabalin
₹8053.8-52815.18 - 22897-99-0
₹27700
Suppliers and manufacturers
Bulat Pharmaceutical Pvt Ltd
Honour Lab Limited
CLEARSYNTH LABS LTD.
Pharmaffiliates Analytics and Synthetics P. Ltd
CLEANCHEM LABORATORIES LLP
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
Capot Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.