U 18666A
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- ₹11040 - ₹39880
- Product name: U 18666A
- CAS: 3039-71-2
- MF: C25H42ClNO2
- MW: 424.06
- EINECS:
- MDL Number:MFCD00210908
- Synonyms:U 18666A;3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL;3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL;3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE;(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE;(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE;U18666A,HCl;(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberU3633
- Product descriptionU 18666A powder
- Packaging5MG
- Price₹11040
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number662015
- Product descriptionU18666A - CAS 3039-71-2 - Calbiochem A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transpo
- Packaging10MG
- Price₹15469.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberU3633
- Product descriptionU 18666A powder
- Packaging25MG
- Price₹39880
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | U3633 | U 18666A powder | 5MG | ₹11040 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 662015 | U18666A - CAS 3039-71-2 - Calbiochem A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transpo | 10MG | ₹15469.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | U3633 | U 18666A powder | 25MG | ₹39880 | 2022-06-14 | Buy |
Properties
Melting point :195-196.5 °C(lit.)
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
Safety Information
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Description
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.Related product price
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