LDN-57444
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- ₹11961.63 - ₹47565.05
- Product name: LDN-57444
- CAS: 668467-91-2
- MF: C17H11Cl3N2O3
- MW: 397.64
- EINECS:
- MDL Number:MFCD09037562
- Synonyms:LDN-57444;5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione3-(O-acetyloxime);LDN-57444/LDN57444;1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime);5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) LDN 57444;3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione;UCH-L1 Inhibitor;(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
4 prices
Selected condition：
Brand
- Sigma-Aldrich
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich
- Product number662086
- Product descriptionUCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
- Packaging10MG
- Price₹14260
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberL4170
- Product descriptionLDN-57444 ≥98% (HPLC)
- Packaging5MG
- Price₹11961.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number662086
- Product descriptionUCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily us
- Packaging10MG
- Price₹14260
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberL4170
- Product descriptionLDN-57444 ≥98% (HPLC)
- Packaging25MG
- Price₹47565.05
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 662086 | UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. | 10MG | ₹14260 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L4170 | LDN-57444 ≥98% (HPLC) | 5MG | ₹11961.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 662086 | UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily us | 10MG | ₹14260 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L4170 | LDN-57444 ≥98% (HPLC) | 25MG | ₹47565.05 | 2022-06-14 | Buy |
Properties
Boiling point :534.4±60.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble16mg/mL
form :solid
pka :-2.57±0.20(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble16mg/mL
form :solid
pka :-2.57±0.20(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Safety Information
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Description
The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.More related product prices
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