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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >GPCR & G Protein >S1P Receptor Inhibitors >SKI II

SKI II

SKI II Structure
  • ₹17568.98 - ₹78481.25
  • Product name: SKI II
  • CAS: 312636-16-1
  • MF: C15H11ClN2OS
  • MW: 302.78
  • EINECS:
  • MDL Number:MFCD00733553
  • Synonyms:Sphingosine Kinase Inhibitor;Sphingosine Kinase Inhibitor 2;SKI II (SphK-I2);SphK-I2;SKI II (Sphingosine Kinase Inhibitor);Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-;4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol SKI II;4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberS5696
  • Product descriptionSKI II ≥98% (HPLC), solid
  • Packaging10MG
  • Price₹17568.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS5696
  • Product descriptionSKI II ≥98% (HPLC), solid
  • Packaging50MG
  • Price₹78481.25
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) S5696 SKI II ≥98% (HPLC), solid 10MG ₹17568.98 2022-06-14 Buy
Sigma-Aldrich(India) S5696 SKI II ≥98% (HPLC), solid 50MG ₹78481.25 2022-06-14 Buy

Properties

Boiling point :507.1±60.0 °C(Predicted)
Density :1.415±0.06 g/cm3(Predicted)
RTECS :SK5900000
storage temp. :2-8°C
solubility :DMSO: ≥20 mg/mL
form :solid
pka :10.17±0.26(Predicted)
color :off-white
Sensitive :Air & Light Sensitive
CAS DataBase Reference :312636-16-1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 M); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. SKI II induces apoptosis and inhibits prpliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM).

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Suppliers and manufacturers

Career Henan Chemica Co
SKI II
₹1.00 /1g
SKI II CAS:312636-16-1
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