Cabazitaxel
- ₹7815.65 - ₹31587.35
- Product name: Cabazitaxel
- CAS: 183133-96-2
- MF: C45H57NO14
- MW: 835.93
- EINECS:680-632-7
- MDL Number:MFCD18827611
- Synonyms:(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;XRP 6258;Cabazitaxel;β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl;7β, 10β-DiMethoxydocetaxel;Cabazitaxel(XRP-6258)
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML2487
- Product descriptionCabazitaxel ≥95% (HPLC)
- Packaging5MG
- Price₹7815.65
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2487
- Product descriptionCabazitaxel ≥95% (HPLC)
- Packaging25MG
- Price₹31587.35
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML2487 | Cabazitaxel ≥95% (HPLC) | 5MG | ₹7815.65 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML2487 | Cabazitaxel ≥95% (HPLC) | 25MG | ₹31587.35 | 2022-06-14 | Buy |
Properties
Melting point :180 °C
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Safety Information
Symbol(GHS): | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .
More related product prices
Afatinib (BIBW 2992) Erlotinib hydrochloride Alisertib (MLN8237) Imatinib Ceritinib (LDK378) (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid Paclitaxel 10-Deacetylbaccatin III (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid 7-O-(TRIETHYLSILYL) BACCATIN III Deacetyltaxol 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III Diethyl RivastigMine Docetaxel 139306-10-8Related product price
- Imatinib
₹5100-26800 - Paclitaxel
₹549-168790.01 - 10-Deacetylbaccatin III
₹7500-20545.85