CHIR-99021
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- ₹8000 - ₹47230.5
- Product name: CHIR-99021
- CAS: 252917-06-9
- MF: C22H18Cl2N8
- MW: 465.34
- EINECS:809-015-4
- MDL Number:MFCD11846251
- Synonyms:6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile;CHIR-99021;GSK-3 Inhibitor XVI;3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino];CT 99021(CHIR 99021);6-[2-[4-(2,4-Dichlorophenyl)-5-(4-Methyl-1H-iMidazol-2-yl)pyriMidin-2-ylaMino]ethylaMino]pyridine-3-;CHIR 99021(CT 99021)
6 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberC2943
- Product descriptionCHIR 99021
- Packaging25MG
- Price₹8000
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberC2943
- Product descriptionCHIR 99021
- Packaging100MG
- Price₹18200
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1046
- Product descriptionCHIR99021 ≥98% (HPLC)
- Packaging5MG
- Price₹11710.5
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361559
- Product descriptionGSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC?? = 10 and 6.7 nM agains
- Packaging5MG
- Price₹24590.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361571
- Product descriptionInSolution GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem InSolution GSK-3 Inhibitor XVI, CHIR99021, CAS 252917-06-9, is a 25 mM solution in DMSO. A cell-permeable, ATP-competitive inhibitor of GSK-3 (IC?? =
- Packaging5MG
- Price₹25800.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1046
- Product descriptionCHIR99021 ≥98% (HPLC)
- Packaging25MG
- Price₹47230.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | C2943 | CHIR 99021 | 25MG | ₹8000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2943 | CHIR 99021 | 100MG | ₹18200 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML1046 | CHIR99021 ≥98% (HPLC) | 5MG | ₹11710.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 361559 | GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC?? = 10 and 6.7 nM agains | 5MG | ₹24590.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 361571 | InSolution GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem InSolution GSK-3 Inhibitor XVI, CHIR99021, CAS 252917-06-9, is a 25 mM solution in DMSO. A cell-permeable, ATP-competitive inhibitor of GSK-3 (IC?? = | 5MG | ₹25800.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1046 | CHIR99021 ≥98% (HPLC) | 25MG | ₹47230.5 | 2022-06-14 | Buy |
Properties
Boiling point :784.1±70.0 °C(Predicted)
Density :1.48
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :11.92±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :AQGNHMOJWBZFQQ-UHFFFAOYSA-N
CAS DataBase Reference :252917-06-9
Density :1.48
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :11.92±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :AQGNHMOJWBZFQQ-UHFFFAOYSA-N
CAS DataBase Reference :252917-06-9
Safety Information
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Description
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.Related product price
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![6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile](https://img.chemicalbook.com/ProductImageEN/2018-12/small/a8d9b725-3501-41e9-8ab0-ffa7fdbdccca.jpg){kind=small}