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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >Rho inhibitor >EHT1864

EHT1864

EHT1864 Structure
  • ₹69723.83
  • Product name: EHT1864
  • CAS: 754240-09-0
  • MF: C25H27F3N2O4S2HCl
  • MW: 0
  • EINECS:
  • MDL Number:MFCD11114384
  • Synonyms:5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride;EHT 1864;2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2);EHT 1864, >=98%;2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride;CS-1239;CS-1343;EHT-1864;EHT-1864
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberE1657
  • Product descriptionEHT 1864 ≥98% (HPLC)
  • Packaging10MG
  • Price₹69723.83
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) E1657 EHT 1864 ≥98% (HPLC) 10MG ₹69723.83 2022-06-14 Buy

Properties

Melting point :>195°C (dec.)
storage temp. :2-8°C
solubility :H2O: soluble10mg/mL, clear
form :powder
color :white to beige
CAS DataBase Reference :754240-09-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.

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career henan chemical co
EHT 1864
₹1.00 /1KG
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TargetMol Chemicals Inc.
EHT 1864
₹39.00 /1mg
EHT 1864 CAS:754240-09-0
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