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JNJ 63533054

JNJ 63533054 Structure
  • ₹10954.9 - ₹44057.75
  • Product name: JNJ 63533054
  • CAS: 1802326-66-4
  • MF: C17H17ClN2O2
  • MW: 316.78
  • EINECS:
  • MDL Number:MFCD29924732
  • Synonyms:JNJ 63533054;3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide;CS-2223;JNJ-63533054 (JNJ63533054;Benzamide, 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-;JNJ-63533054 >=98% (HPLC);(S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide;L-tryptophan,blood-brain,oral,CNS,L-phenylalanine,G Protein-Coupled Receptor 139,barrier,JNJ63533054,Inhibitor,GPR139,JNJ-63533054,inhibit
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1624
  • Product descriptionJNJ-63533054 ≥98% (HPLC)
  • Packaging25MG
  • Price₹44057.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1624
  • Product descriptionJNJ-63533054 ≥98% (HPLC)
  • Packaging5MG
  • Price₹10954.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1624 JNJ-63533054 ≥98% (HPLC) 25MG ₹44057.75 2022-06-14 Buy
Sigma-Aldrich(India) SML1624 JNJ-63533054 ≥98% (HPLC) 5MG ₹10954.9 2022-06-14 Buy

Properties

Boiling point :559.7±45.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble in DMSO (up to 35 mg/ml).
form :powder
pka :12.77±0.46(Predicted)
color :white to beige
optical activity :[α]/D -89 to -99°, c = 1 in ethanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

JNJ-63533054 (1802326-66-4) is a potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1?Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2?Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3?Suppresses morphine intake in a mouse self-administration model.4

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