Moxonidine
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- ₹5400 - ₹18600
- Product name: Moxonidine
- CAS: 75438-57-2
- MF: C9H12ClN5O
- MW: 241.68
- EINECS:629-833-3
- MDL Number:MFCD06795643
- Synonyms:MOXONIDINE;MOXONIDINE HCL;4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin ;bdf5895 ;be5895 ;BDF-5895 HCL;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
2 prices
Selected condition:
Brand
- TCI Chemicals (India)
Package
- 200MG
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberM2660
- Product descriptionMoxonidine
- Packaging200MG
- Price₹5400
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberM2660
- Product descriptionMoxonidine
- Packaging1G
- Price₹18600
- Updated2022-05-26
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | M2660 | Moxonidine | 200MG | ₹5400 | 2022-05-26 | Buy |
TCI Chemicals (India) | M2660 | Moxonidine | 1G | ₹18600 | 2022-05-26 | Buy |
Properties
Melting point :217-219° (dec)
Boiling point :364.7±52.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form :Solid
pka :7.11±0.10(Predicted)
color :White to Almost white
Water Solubility :800.3mg/L(temperature not stated)
Merck :14,6293
InChIKey :WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference :75438-57-2(CAS DataBase Reference)
Boiling point :364.7±52.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form :Solid
pka :7.11±0.10(Predicted)
color :White to Almost white
Water Solubility :800.3mg/L(temperature not stated)
Merck :14,6293
InChIKey :WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference :75438-57-2(CAS DataBase Reference)
Safety Information
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Signal word: | Danger | |||||||||||||||||||||
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Description
Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.
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