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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >P2 Receptor Antagonists >MRS 2578

MRS 2578

MRS 2578 Structure
  • ₹13011.65 - ₹52609.5
  • Product name: MRS 2578
  • CAS: 711019-86-2
  • MF: C20H20N6S4
  • MW: 472.67
  • EINECS:200-258-5
  • MDL Number:MFCD07370141
  • Synonyms:N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA];MRS 2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N',N'''-butane-1,4-diylbis[1-(3-isothiocyanatophenyl)(thiourea)];Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-;MRS 2578;MRS-2578; MRS2578;MRS 2578 >=95% (HPLC);Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)- (9CI)
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberM0319
  • Product descriptionMRS 2578 ≥95% (HPLC)
  • Packaging5MG
  • Price₹13011.65
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM0319
  • Product descriptionMRS 2578 ≥95% (HPLC)
  • Packaging25MG
  • Price₹52609.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) M0319 MRS 2578 ≥95% (HPLC) 5MG ₹13011.65 2022-06-14 Buy
Sigma-Aldrich(India) M0319 MRS 2578 ≥95% (HPLC) 25MG ₹52609.5 2022-06-14 Buy

Properties

Melting point :170 - 173°C
Boiling point :652.7±65.0 °C(Predicted)
Density :1.31
storage temp. :2-8°C
solubility :DMSO: ~17 mg/mL
form :solid
pka :11.80±0.70(Predicted)
color :white
InChIKey :QOHNRGHTJPFMSL-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MRS 2578, a symmetric aryl diisothiocyanate derivative, is shown to be an inhibitor of P2Y6 receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions. P2Y receptor activation has been reported to induce phospholipase C activity. Further studies reveal that P2Y6 receptors can cause microglial phagocytosis as well as activation of P38 MAPK and expression of COX-2 in cells exposed to UVB radiation. MRS 2578 is an inhibitor of P2Y66.

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