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ChemicalBook > Product Catalogue >Biochemical Engineering >Natural Products >Oridonin

Oridonin

Oridonin Structure
  • ₹10670 - ₹55737.93
  • Product name: Oridonin
  • CAS: 28957-04-2
  • MF: C20H28O6
  • MW: 364.44
  • EINECS:
  • MDL Number:MFCD00221762
  • Synonyms:Oridonin, R. rubescens;ISODONAL;(14r)-7-alpha,20-epoxy-1-alpha,6-beta,7,14-tetrahydroxykaur-16-en-15-one ;(1-alpha,6-beta,7-alpha,14r)-7,20-epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-o ;,14r)- ;20-epoxy-1-alpha,6-beta,7,14-tetrahydroxy-7-alph(14r)-kaur-16-en-15-on ;kaur-16-en-15-one,7,20-epoxy-1,6,7,14-tetrahydroxy-,(1-alpha,6-beta,7-alpha ;Rubescensin
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number496915
  • Product descriptionOridonin, R. rubescens - CAS 28957-04-2 - Calbiochem A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.
  • Packaging5MG
  • Price₹10670
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO9639
  • Product descriptionOridonin ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹13964.25
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO9639
  • Product descriptionOridonin ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹55737.93
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 496915 Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties. 5MG ₹10670 2022-06-14 Buy
Sigma-Aldrich(India) O9639 Oridonin ≥98% (HPLC), solid 5MG ₹13964.25 2022-06-14 Buy
Sigma-Aldrich(India) O9639 Oridonin ≥98% (HPLC), solid 25MG ₹55737.93 2022-06-14 Buy

Properties

Melting point :248-250°C
Boiling point :599.8±50.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO: >20mg/mL
form :Yellow solid
pka :10.96±0.70(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey :SDHTXBWLVGWJFT-WNKSEERENA-N
SMILES :O[C@@]12OC[C@]3([C@H](CCC(C)(C)[C@@]3([H])[C@@H]1O)O)[C@]1([H])CC[C@@]3([H])C(=C)C(=O)[C@@]21C3([H])O |&1:1,4,5,11,13,16,20,26,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 ~ 2.7 g/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 g/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 ~ 5 g/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.

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