2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
- ₹0
- Product name: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
- CAS: 404951-53-7
- MF: C22H25N3O3
- MW: 379.45
- EINECS:
- MDL Number:
- Synonyms:2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-;Dacinostat(NVP-LAQ 824);LAQ-824;LAQ824 (Dacinostat);(E)-3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide;(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide;3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid;LAQ824(NVP-LAQ824,Dacinostat)
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.290±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥17.45 mg/mL in DMSO
form :solid
pka :8.81±0.23(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥17.45 mg/mL in DMSO
form :solid
pka :8.81±0.23(Predicted)
color :Light yellow to yellow
Safety Information
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Description
LAQ824 is a hydroxamate-based inhibitor of histone deacetylases (HDACs) with an IC50 value of 30 nM. It inhibits the growth of colon, breast, prostate, and non-small cell lung cancer cell lines at concentrations of less than 1 μM. LAQ824 augments the actions of fludarabine and imatinib mesylate in human leukemia cells. Through its effects on HDACs, LAQ824 induces acetylation of histones, α-tubulin, and heat shock protein 90 (Hsp90). Acetylation of Hsp90 blocks its chaperone function, resulting in changes in levels of several client proteins, including estrogen receptor-α, Hsp72, and Raf-1.More related product prices
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Suppliers and manufacturers
Shaanxi Haibo Biotechnology Co., Ltd
₹0.00 /25kg
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- CAS:404951-53-7
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- CAS:404951-53-7
career henan chemical co
A.J Chemicals
Shanghai Daken Advanced Materials Co.,Ltd
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
InvivoChem
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Nantong HI-FUTURE Biology Co., Ltd.
₹1.00 /100g
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- CAS:404951-53-7
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- CAS:404951-53-7