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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >MEK inhibitor >PD184352

PD184352

PD184352 Structure
  • ₹9800 - ₹51884.23
  • Product name: PD184352
  • CAS: 212631-79-3
  • MF: C17H14ClF2IN2O2
  • MW: 478.66
  • EINECS:
  • MDL Number:MFCD02683961
  • Synonyms:PD184352;2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE;2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-;Ci-1040;CI-1040, PD-184352;3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberP2174
  • Product descriptionPD 184352
  • Packaging25MG
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2174
  • Product descriptionPD 184352
  • Packaging100MG
  • Price₹32500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0181
  • Product descriptionPD184352 ≥98% (HPLC)
  • Packaging5MG
  • Price₹12979.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0181
  • Product descriptionPD184352 ≥98% (HPLC)
  • Packaging25MG
  • Price₹51884.23
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2174 PD 184352 25MG ₹9800 2022-05-26 Buy
TCI Chemicals (India) P2174 PD 184352 100MG ₹32500 2022-05-26 Buy
Sigma-Aldrich(India) PZ0181 PD184352 ≥98% (HPLC) 5MG ₹12979.18 2022-06-14 Buy
Sigma-Aldrich(India) PZ0181 PD184352 ≥98% (HPLC) 25MG ₹51884.23 2022-06-14 Buy

Properties

Melting point :166-169°C
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate). It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model. The second-generation MEK inhibitor PD 0325901 is a structural derivative of CI-1040 that was developed for improved solubility.

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