PF-03814735
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- ₹11528.63 - ₹46515.03
- Product name: PF-03814735
- CAS: 942487-16-3
- MF: C23H25F3N6O2
- MW: 474.48
- EINECS:-0
- MDL Number:MFCD16659065
- Synonyms:PF-03814735;N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide;Acetamide, N-[2-[(1S,4R)-6-[[4-(cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-;RYYNGWLOYLRZLK-RBUKOAKNSA-N;CS-240;PF-03814735 USP/EP/BP;Abecarnil Impurity 3;PF-03814735 PF03814735
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0218
- Product descriptionPF-03814735 ≥98% (HPLC)
- Packaging5MG
- Price₹11528.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0218
- Product descriptionPF-03814735 ≥98% (HPLC)
- Packaging25MG
- Price₹46515.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PZ0218 | PF-03814735 ≥98% (HPLC) | 5MG | ₹11528.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PZ0218 | PF-03814735 ≥98% (HPLC) | 25MG | ₹46515.03 | 2022-06-14 | Buy |
Properties
Melting point :181-183°C
Density :1.443
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :15.02±0.46(Predicted)
color :white to beige
Density :1.443
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :15.02±0.46(Predicted)
color :white to beige
Safety Information
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Description
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.Related product price
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