WYE-354
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- ₹26250
- Product name: WYE-354
- CAS: 1062169-56-5
- MF: C24H29N7O5
- MW: 495.53
- EINECS:-0
- MDL Number:MFCD18074514
- Synonyms:WYE-354;4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;WYE-354 (Degrasyn);WYE-354;WYE 354; WYE354;Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip;CS-441;1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number475986
- Product descriptionmTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 - Calbiochem The mTOR Kinase Inhibitor II, WYE-354, also referenced under CAS 1062169-56-5, controls the biological activity of mTOR. This small molecule/inhibitor
- Packaging5MG
- Price₹26250
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 475986 | mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 - Calbiochem The mTOR Kinase Inhibitor II, WYE-354, also referenced under CAS 1062169-56-5, controls the biological activity of mTOR. This small molecule/inhibitor | 5MG | ₹26250 | 2022-06-14 | Buy |
Properties
Density :1.46
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white
Safety Information
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Description
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC50 = 1026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.Related product price
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