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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >Ferroptosis activator >2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone Structure
CAS No.
571203-78-6
Chemical Name:
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
Synonyms
Moxeza;2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one;Erastin;CS-1430;Erastin - CAS 571203-78-6 - Calbiochem;2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one;2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-on;2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone;2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-
CBNumber:
CB02098795
Molecular Formula:
C30H31ClN4O4
Molecular Weight:
547.04
MOL File:
571203-78-6.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone Properties

Boiling point 721.9±70.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka 5.54±0.10(Predicted)
form White solid
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference 571203-78-6

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2933599590
NFPA 704
0
2 0

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) E7781 Erastin ≥98% (HPLC) 571203-78-6 1MG ₹15631.3 2022-06-14 Buy
Sigma-Aldrich(India) E7781 Erastin ≥98% (HPLC) 571203-78-6 5MG ₹62319.53 2022-06-14 Buy
Sigma-Aldrich(India) 329600 Erastin - CAS 571203-78-6 - Calbiochem A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. 571203-78-6 5MG ₹16460 2022-06-14 Buy
Product number Packaging Price Buy
E7781 1MG ₹15631.3 Buy
E7781 5MG ₹62319.53 Buy
329600 5MG ₹16460 Buy

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone Chemical Properties,Uses,Production

Description

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox , ferrostatin-1 , U-0126 , cycloheximide , and β-mercaptoethanol. Erastin (5 μM) inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells and inhibits glutamate release in an enzyme-coupled fluorescence assay (EC50 = 1.2 μM). It also selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 μg/ml).

Uses

Erastin, named for eradicator of RAS and ST-expressing cells, is an irreversible antitumor agent that selectively kills cells expressing the small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 μg/ml). It produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel gating, allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.[Cayman Chemical]

General Description

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone Suppliers

Global( 150)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nanjing Doge Biomedical Technology Co., Ltd 58

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone Spectrum

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone(571203-78-6)1HNMR

571203-78-6(2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone)Related Search:

Simvastatin TYRPHOSTIN AG 1296 Brefeldin A 3-Aminobenzamide Ribonucleic acid
DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Glutathione MK-2206 2HCl ABT-199 SB 431542
OLIGOMYCIN A Ferrostatin-1 (Fer-1) Olaparib clofexamide 2-(4-CHLORO-PHENOXY)-1-PIPERAZIN-1-YL-ETHANONE
2-(1-METHYLAMINOETHYL)-3-PHENYL-3H-QUINAZOLIN-4-ONE 3-METHYL-2-(1-METHYLAMINOETHYL)-3H-QUINAZOLIN-4-ONE Erastin
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2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)- 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone Erastin 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-on Erastin Erastin - CAS 571203-78-6 - Calbiochem 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone USP/EP/BP CS-1430 Moxeza 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4(3H)-one 571203-78-6 C30H31ClN4O4 Inhibitors API