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DL-Mevalonolactone

CAS No.: 674-26-0

Chemical Name:: DL-Mevalonolactone

Synonyms: NSC 90804;Beta-Hydro;Hyperpure-MVA;MEVALONOLACTONE;DL-MEVALOLACTONE;MEVALONIC LACTONE;DL-MEVALONOLACTONE;(+/-)-MEVALONOLACTONE;Adeka Mevalonolactone;DL-Mevalonolactone >

CBNumber:: CB0377087

Molecular Formula:: C6H10O3

Molecular Weight:: 130.14

MOL File:: 674-26-0.mol

Modify Date:: 2024/5/14 17:56:46

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DL-Mevalonolactone Properties

Melting point	28 °C(lit.)
Boiling point	145-150 °C5 mm Hg(lit.)
alpha	-1.0～+1.0°(20℃/D)(c=5, C2H5OH)
Density	1.1066 (rough estimate)
refractive index	n20/D 1.473(lit.)
Flash point	>230 °F
storage temp.	-20°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)
form	Oil
pka	13.57±0.20(Predicted)
color	Pale Yellow to Dark Brown
Merck	14,6163
BRN	80960
Stability	Hygroscopic
InChIKey	JYVXNLLUYHCIIH-UHFFFAOYSA-N
CAS DataBase Reference	674-26-0(CAS DataBase Reference)
NIST Chemistry Reference	Dl-mevalonic acid lactone(674-26-0)

SAFETY

Risk and Safety Statements

WGK Germany

3-10

HS Code

29322090

NFPA 704

	1
1		0

DL-Mevalonolactone price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M4667	(±)-Mevalonolactone ~97% (titration)	674-26-0	1G	₹13098.25	2022-06-14	Buy
Sigma-Aldrich(India)	M4667	(±)-Mevalonolactone ~97% (titration)	674-26-0	5G	₹37887.5	2022-06-14	Buy
Sigma-Aldrich(India)	M4667	(±)-Mevalonolactone ~97% (titration)	674-26-0	10G	₹51678.55	2022-06-14	Buy
TCI Chemicals (India)	D0587	DL-Mevalonolactone min. 98.0 %	674-26-0	100MG	₹3200	2022-05-26	Buy

Product number	Packaging	Price	Buy
M4667	1G	₹13098.25	Buy
M4667	5G	₹37887.5	Buy
M4667	10G	₹51678.55	Buy
D0587	100MG	₹3200	Buy

DL-Mevalonolactone Chemical Properties,Uses,Production

Description

DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite from endophytes of the medicinal plant Erythrina crista-galli.

General Description

Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.

Purification Methods

Purify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]

DL-Mevalonolactone Preparation Products And Raw materials

Raw materials

Preparation Products

3-METHYLPENTANE-1,3,5-TRIOL

DL-Mevalonolactone Suppliers

Global( 221)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
Wuhan Quanjinci New Material Co.,Ltd.	+8615271838296	China	1534	58	Inquiry
airuikechemical co., ltd.	+undefined86-15315557071	China	983	58	Inquiry
BINBO BIOLOGICAL CO.,LTD	+8618629063126	China	346	58	Inquiry
Accela ChemBio Inc.	+1-858-6993322	United States	19479	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry

Supplier	Advantage
TCI Chemicals (India) Pvt. Ltd.	58
CLEARSYNTH LABS LTD.	58
Clearsynth Labs	58
Alfa Aesar	58
Hebei Yanxi Chemical Co., Ltd.	58
Wuhan Quanjinci New Material Co.,Ltd.	58
airuikechemical co., ltd.	58
BINBO BIOLOGICAL CO.,LTD	58
Accela ChemBio Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

DL-Mevalonolactone Spectrum

DL-Mevalonolactone(674-26-0)MS DL-Mevalonolactone(674-26-0)¹HNMR DL-Mevalonolactone(674-26-0)¹³CNMR DL-Mevalonolactone(674-26-0)IR1 DL-Mevalonolactone(674-26-0)Raman

674-26-0(DL-Mevalonolactone)Related Search:

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Triclosan Ethyl 2-(Chlorosulfonyl)acetate 3,5-Dihydroxybenzoic acid

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DL-MEVALONOLACTONE β-Hydroxy-β-methyl-δ-valerolactone, (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, (±)-Mevalolactone, (±)-Mevalonic acid lactone, (±)-Mevalonolactone (4S)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one (S)-3,5-Dihydroxy-3-methylpentanoic acid δ-lactone (S)-4β-Hydroxy-4-methyltetrahydro-2H-pyran-2-one (S)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one Beta-Hydro (±)-Mevalonolactone,(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone Tetrahydro-4-hydroxy-4-Methyl- beta-Hydroxy-beta-methyl-delta-valerolactone DL-Mevalonic Acid Lactone Tetrahydro-4-hydroxy-4-methyl-2-pyrone tetrahydro-4-hydroxy-4-Methylpyran-2-one DL-MEVALOLACTONE DL-MEVALONIC ACID LACTONE DL-BETA-HYDROXY-BETA-METHYL-DELTA-VALERO-LACTONE DL-BETA-HYDROXY-BETA-METHYL-GAMMA-VALEROLACTONE DL-BETA-HYDROXY-BETA-METHYL-G-VALEROLACTONE DL-3-HYDROXY-3-METHYL DELTA-VALEROLACTONE BETA-HYDROXY-BETA-METHYL-DELTA-VALEROLACTONE MEVALONIC ACID LACTONE, DL- MEVALONIC LACTONE (+/-)-MEVALONOLACTONE MEVALONOLACTONE (+/-)-3-HYDROXY-3-METHYL-5-PENTANOLIDE (4R)-4-Hydroxy-4-methyl-oxan-2-one (+/-)-tetrahydro-4-hydroxy-4-methyl-2h-pyran-2-one TETRAHYDRO-4-HYDROXY-4-METHYL-2-PYRONE 2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (.+/-.)- 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one D,L-b-Hydroxy-b-methyl-valerolactone (±)-β-hydroxy-β-methyl-δ-valerolactone MEVALONIC ACID LACTONE, DL-(RG) D,L-MEVELONIC ACID LACTONE DL-B-HYDROXY-B-METHYL-Y-VALEROLACTONE D,L--Hydroxy--methyl--valerolactone NSC 90804 (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone dl-mevalonic acid lactone, salt-free DL-Mevalonolactone > Mevalonolactone, racemic mixture 4-hydroxy-4-methyloxan-2-one 4-Hydroxy-4-methyltetrahydropyran-2-one Hyperpure-MVA Adeka Mevalonolactone 674-26-0 Organic Building Blocks Lactones Metabolomics Metabolic Libraries Lipid Library Building Blocks BioChemical Carbonyl Compounds Heterocycles, Metabolites & Impurities Heterocycles Metabolites & Impurities